In a Nature article published earlier this week, UK and US researchers have provided more proof that smoking has a direct effect on the development of small-cell lung cancer. This study describes 22,910 somatic mutations characterized by massively parallel sequencing technology (including 134 in highly important exon coding regions) in the small-cell lung cancer cell line NCI-H209 (karyotype pictured). These mutations disrupt many of the pathways that are vital to preservation of cell growth and division regulation.
As the authors note, the more than 60 carcinogenic chemicals in cigarettes greatly increase the number of mutations by binding and chemically modifying DNA, thus increasing the presence of cancer in lunch cells due to cancer being driven by mutations. This has been suggested to explain the 20x increase in cancer in smoking patients than in non-smoking patients.
This study has provided a huge amount of mutation information for small-cell lung cancer research and will likely lead to vast increases in identifying the specific chemical causes of each mutation.
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2 Comments
Wow! That is pretty intense! I never imagined that smoking has THAT much of an affect on the lungs! I mean sure, I have researched its negative affects but I never fully understood why more cancer patients are those that have previously smoked. I read parts of the nature article and read on mskcc.org (memorial sloan-kettering cancer center) that they also state that smoking is one of the biggest factors for lung cancer development. They also say that secondhand lung cancer is caused by mostly tobacco inhale, which as stated in the nature article again as a disease where genetic mutations form in the lungs. Great summary of Nature’s article but I have a question for Jyaron: Are the mutations in lung cells as severe in secondhand lung cancer patients as they are in first hand lung cancer patients?
I heard many things about smoking being bad for people’s health. But, all I heard was that smoking increases the risk of lung cancer and smoking can become life threatening (maybe small chance). The article (your article) I just read was pretty intense, I didn’t know smoking would cause that much of a problem to the lungs.
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