More Proof That Smoking Leads to Small-Cell Lung Cancer

In a Nature article published earlier this week, UK and US researchers have provided more proof that smoking has a direct effect on the development of small-cell lung cancer. This study describes 22,910 somatic mutations characterized by massively parallel sequencing technology (including 134 in highly important exon coding regions) in the small-cell lung cancer cell line NCI-H209 (karyotype pictured). These mutations disrupt many of the pathways that are vital to preservation of cell growth and division regulation.

As the authors note, the more than 60 carcinogenic chemicals in cigarettes greatly increase the number of mutations by binding and chemically modifying DNA, thus increasing the presence of cancer in lunch cells due to cancer being driven by mutations. This has been suggested to explain the 20x increase in cancer in smoking patients than in non-smoking patients.

This study has provided a huge amount of mutation information for small-cell lung cancer research and will likely lead to vast increases in identifying the specific chemical causes of each mutation.

Read the original article at Nature as an Advanced Online Publication: A small-cell lung cancer genome with complex signatures of tobacco exposure.

Related posts:

  1. Cancer Motility Mechanisms Observed
  2. Visualize the Unbelievably Small Scale of the Cell (and other Biological Structures)
  3. Baylor researchers find fat cell blocker
  4. RNA Interference Technology Will Improve Pharmaceutical Production
  5. Evidence for Environmental and Epigenetic Cause of Autism

This entry was posted in Biology, Cell Biology, Genetics, Genomics, Health & Medicine and tagged , , , , , , . Bookmark the permalink. Post a comment or leave a trackback: Trackback URL.

2 Comments

  1. Molly
    Posted November 8, 2010 at 12:50 am | Permalink

    Wow! That is pretty intense! I never imagined that smoking has THAT much of an affect on the lungs! I mean sure, I have researched its negative affects but I never fully understood why more cancer patients are those that have previously smoked. I read parts of the nature article and read on mskcc.org (memorial sloan-kettering cancer center) that they also state that smoking is one of the biggest factors for lung cancer development. They also say that secondhand lung cancer is caused by mostly tobacco inhale, which as stated in the nature article again as a disease where genetic mutations form in the lungs. Great summary of Nature’s article but I have a question for Jyaron: Are the mutations in lung cells as severe in secondhand lung cancer patients as they are in first hand lung cancer patients?

  2. Alexandria C.
    Posted September 21, 2011 at 6:30 pm | Permalink

    I heard many things about smoking being bad for people’s health. But, all I heard was that smoking increases the risk of lung cancer and smoking can become life threatening (maybe small chance). The article (your article) I just read was pretty intense, I didn’t know smoking would cause that much of a problem to the lungs.

3396 Trackbacks

  1. By Aliceville Great Clips Coupons on February 2, 2012 at 1:36 pm

    Great Clips Coupons…

    [...]these are a few links to internet websites that we connect to as we believe they are definitely worth checking out[...]…

  2. By plush dragon on February 2, 2012 at 3:02 pm

    where to buy Premier and Stitched France jerseys dragon plush…

    [...]we adivce go to this website to see more about France jerseys and others.[...]…

  3. By Saints Tickets on February 2, 2012 at 5:28 pm

    Websites worth visiting…

    I enjoyed reading your article, many thanks….

  4. By iPhone 5 Release Date on February 2, 2012 at 6:47 pm

    iPhone 5 Release Date…

    [...]just below, are some totally unrelated sites to ours, however, they are definitely worth checking out[...]…

  5. By cheap viagra on February 2, 2012 at 7:28 pm

    Amazing site…

    I really liked your blog, thanks for sharing this useful information……

  6. By stelivo on February 2, 2012 at 7:30 pm

    [...]we like to honor many other internet sites on the web, even if they aren’t linked to us, by linking to them. Under are some webpages worth checking out[...]……

    [...]Here are some of the sites we recommend for our visitors[...]……

  7. By single moms grants on February 2, 2012 at 9:27 pm

    Awesome website…

    Really nice blog. I will check back for more information on this subject later….

  8. By social media marketing for music industry on February 3, 2012 at 12:43 am

    Read was interesting, stay in touch……

    [...] will take fairly long time for building great results. One should have real perseverance [...]…

  9. By Great Clips on February 3, 2012 at 1:30 am

    Great Clips Coupons…

    [...]in the following are some web page links to internet sites I always connect to as we think they’re worth browsing[...]…

  10. By Cheap LED Light Bulbs on February 3, 2012 at 1:45 am

    Great article.Much thanks again. Will read on……

    I cannot thank you enough for the article.Really thank you! Awesome….

  11. By hosting on February 3, 2012 at 4:03 am

    Website worth visiting…

    below you’ll find the link to some sites that we think you should visit…

  12. By cialis on February 3, 2012 at 4:24 am

    Great information…

    This is often amazing. That is why we looked at tips gist when we are stupefied. We are precisely fascinated by this kind of meals. Individuals appreciate ones guide, and estimate the effort with this. Please keep control. These are incredibly advantag…

  13. By mens trench coats on February 3, 2012 at 4:29 am

    Favorite webpage…

    [...] only a few sites that had been detailed below, from our standpoint are without any doubt well worth reading [...]…

  14. By Kamasz on February 3, 2012 at 5:17 am

    Kamasz…

    [...]we like to honor other sites on the web, even if they aren’t related to us, by linking to them. Below are some sites worth checking out[...]…

  15. By Deidre on February 3, 2012 at 6:55 am

    News info…

    [...]I was reading the news and I saw this really interesting topic[...]…

  16. By affiliate on February 3, 2012 at 7:08 am

    Trackback…

    [...]Dear Webmaster, check out this new way to make money for your blog through Facebook [...]…

  17. By iPhone 5 on February 3, 2012 at 7:28 am

    iPhone 5…

    [...]here are some links to sites that we link to because we think they are worth visiting[...]…

  18. By click here for garmin on February 3, 2012 at 10:18 am

    Garmin 1490t…

    [...]below you’ll find the link to some sites that we think you should visit[...]…

  19. By Alabama Great Clips Coupons on February 3, 2012 at 12:51 pm

    Great Clips Coupons…

    [...]listed here are a couple of web links to internet websites that we connect to because we think they will be worth visiting[...]…

  20. By cheap auto insurance on February 3, 2012 at 1:30 pm

    Cool writing…

    [...]I am forever thought about this, thankyou for putting up.[...]…

  21. By cuckold phone sex on February 3, 2012 at 2:19 pm

    Awesome site…

    [...] undoubtedly one of our site visitors fairly recently commended the following websites [...]…

  22. By Great Clips Coupons Aliceville on February 3, 2012 at 5:51 pm

    Great Clips Coupons…

    [...]listed here are some url links to web-sites which we connect to as we feel these are really worth visiting[...]…

  23. By hosting seo on February 3, 2012 at 6:17 pm

    You should check this out…

    I saw this really great post today….

  24. By hosting on February 3, 2012 at 6:29 pm

    Great website…

    Here are some of the sites we recommend for our visitors…

  25. By apartamenty zakopane on February 3, 2012 at 8:07 pm

    Recommeneded websites…

    Here you’ll find some sites that we think you’ll appreciate, just click the links over…

  26. By Tamil Sex Stories on February 3, 2012 at 9:46 pm

    Read More…

    [...]…Very Creative…[...]…

  27. By Great Clips Online Coupons on February 3, 2012 at 11:11 pm

    Great Clips Coupons…

    [...]the following are some references to internet pages I always link to because we feel they will be worthy of browsing[...]…

  28. By Low Calorie Mushroom and Scallion Chicken Directions on February 3, 2012 at 11:15 pm

    Yahoo results…

    While searching Yahoo I found this page in the results and I didn’t think it fit…

  29. By fan on February 4, 2012 at 12:15 am

    Related Blogs…..

    [...] listed here you’ll discover the link to many sites that a number of us presume you should visit [...]…

  30. By fancy dog bed on February 4, 2012 at 1:35 am

    Buy Discount Dog Beds…

    [...]here are a few links to sites that individuals hyperlink to because we think they’re worth visiting[...]…

  31. By car insurance for 1 day on February 4, 2012 at 6:37 am

    Visitor suggestions…

    [...] we ran into a cool site that you might appreciate. Check it out if you want [...]…

  32. By gry dla dziewczynek on February 4, 2012 at 9:15 am

    Thanks…

    I want, this post. Thank you….

  33. By Montreal wedding photograper on February 4, 2012 at 9:20 am

    Nice Stuff…

    [...]Glad I found this on google[...]…

  34. By Ticket Hub on February 4, 2012 at 10:37 am

    Gems form the internet…

    [...]very few websites that happen to be detailed below, from our point of view are undoubtedly well worth checking out[...]……

  35. By buy quick click commissions on February 4, 2012 at 12:29 pm

    Sources…

    [...]check below, are some totally unrelated websites to ours, however, they are most trustworthy sources that we use[...]……

  36. By Swiss Luxury Watches on February 4, 2012 at 2:43 pm

    Blogs ou should be reading…

    [...]Here is a Great Blog You Might Find Interesting that we Encourage You[...]……

  37. By worm composting forum on February 4, 2012 at 4:14 pm

    Websites we think you should visit…

    [...]although websites we backlink to below are considerably not related to ours, we feel they are actually worth a go through, so have a look[...]……

  38. By közösségi portálok on February 4, 2012 at 5:38 pm

    közösségi portálok…

    [...]just below, are some totally unrelated sites to ours, however, they are definitely worth checking out[...]…

  39. By bodybuilding t shirts on February 4, 2012 at 6:35 pm

    [...]we like to honor many other internet sites on the web, even if they aren’t linked to us, by linking to them. Under are some webpages worth checking out[...]……

    [...]Here are some of the sites we recommend for our visitors[...]……

  40. By Basketball Drills on February 4, 2012 at 7:53 pm

    Basketball Drills…

    [...]the time to read or visit the content or sites we have linked to below the[...]…

  41. By Masala Indian Sex Stories on February 4, 2012 at 9:59 pm

    Read More…

    [...]…Most Helpful…[...]…

  42. By freight tracking on February 4, 2012 at 10:40 pm

    Great website…

    [...]we like to honor many other internet sites on the web, even if they aren’t linked to us, by linking to them. Under are some webpages worth checking out[...]……

  43. By new adidas jerseys on February 5, 2012 at 12:24 am

    Cool sites…

    [...]we came across a cool site that you might enjoy. Take a look if you want[...]……

  44. By 2012 NFL Jerseys on February 5, 2012 at 1:11 am

    where to buy Premier and Stitched Cleveland Cavaliers jerseys ??…

    [...]we adivce go to this website to see more about Cleveland Cavaliers jerseys and others. [...]…

  45. By best diet pill on February 5, 2012 at 1:24 am

    Great information…

    This can be really good. American looked at this excellent joyful and we are astonished. We are interested in this kind of techniques. We appreciate your prefered tape, and assess your time with this. Please keep adding information to. They’re same gr…

  46. By running shoe women sale on February 5, 2012 at 2:17 am

    Websites you should visit…

    [...]below you’ll find the link to some sites that we think you should visit[...]……

Post a Comment

Your email is never published nor shared. Required fields are marked *

*
*

You may use these HTML tags and attributes: <a href="" title=""> <abbr title=""> <acronym title=""> <b> <blockquote cite=""> <cite> <code> <del datetime=""> <em> <i> <q cite=""> <strike> <strong>

*